Snsek-SP-SLR570 Hot and Cold Plate Pain Tester - 副本

Brand: Penncentury SNSEK

Model: Snsek-SP-SLR570

At present, the screening experimental methods (physical methods) for acute pain analgesics are basically hot plate experiments, tail flick reflex experiments or animal foot pain irradiation experiments, but these are the normal stimulation response thresholds of animals and belong to a kind of physiological pain. There is an essential difference between physiological pain and pathological pain. Physiological pain is a set of alarm systems for self-protection for survival, while pathological pain is a disease that hinders survival. Due to the different manifestations and occurrence mechanisms of the two types of pain, the research experimental methods for analgesics are also different. For example, some analgesics have good analgesic effects on both physiological and pathological pain. However, some drugs only work on physiological pain, so different experimental methods and experimental instruments can be used to screen out drugs with different points of action. The hot and cold plate analgesic is an instrument that can complete physiological pain experiments and pathological pain experiments on the same instrument.

When the surface temperature of the hot and cold plate analgesia meter is set to 4℃, the test drug can significantly change the time and number of foot lifting on the cold plate for animals with sciatic nerve pathological pain model. When the surface temperature is set to 55℃, the physiological pain threshold of the animal can be accurately measured to determine the analgesic type and effect of the test drug. The advantage of this experimental method is that the animal is tested in an unrestrained state, avoiding human interference and harm to the animal. It is loved by experimenters because of its simple and convenient operation, clear indicators and more accurate reflection of the pain behavior of animals.

In addition to the basic requirements of wide setting temperature (-5℃~70℃), high temperature control accuracy, and small timing error (error 0.01 seconds), the instrument also has LCD screen Chinese display, built-in micro printer, USB microcomputer interface, fast animal loading, complete data display, convenient animal observation, automatic accumulation of foot lifting time and number of foot lifting, etc. It is a truly dual-purpose analgesic drug experimental instrument.